{"id":1521,"date":"2018-07-04T01:06:34","date_gmt":"2018-07-03T23:06:34","guid":{"rendered":"https:\/\/my-immunity.com\/staging\/?page_id=1521"},"modified":"2018-07-04T14:00:15","modified_gmt":"2018-07-04T12:00:15","slug":"inonotus-obliquus-chaga-it","status":"publish","type":"page","link":"https:\/\/my-immunity.com\/staging\/it\/inonotus-obliquus-chaga-it.html","title":{"rendered":"Inonotus Obliquus (Chaga) IT"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\"  style='background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;'><div class=\"fusion-builder-row fusion-row \"><div  class=\"fusion-layout-column fusion_builder_column fusion_builder_column_1_1  fusion-one-full fusion-column-first fusion-column-last 1_1\"  style='margin-top:0px;margin-bottom:20px;'>\n\t\t\t\t\t<div class=\"fusion-column-wrapper\" style=\"padding: 0px 0px 0px 0px;background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\"  data-bg-url=\"\">\n\t\t\t\t\t\t<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row \"><div  class=\"fusion-layout-column fusion_builder_column fusion_builder_column_3_4  fusion-three-fourth fusion-column-first 3_4\"  style='margin-top: 0px;margin-bottom: 20px;width:75%;width:calc(75% - ( ( 4% ) * 0.75 ) );margin-right:4%;'><div class=\"fusion-column-wrapper\" style=\"padding: 0px 0px 0px 0px;background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\"  data-bg-url=\"\"><div class=\"fusion-text\"><div class=\"content-story clear-block\">\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Chaga Mushroom<\/span><\/strong><\/span><\/div>\n<p><strong>Scientific Name:<\/strong> Inonotus obliquus<\/p>\n<p><strong>Common Name:<\/strong> Cinder conk, birch conk, clinker polypore<\/p>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-1274\" src=\"https:\/\/my-immunity.com\/staging\/wp-content\/uploads\/2018\/06\/inonotus_obliquus.jpg\" alt=\"inonotus_obliquus\" width=\"331\" height=\"198\" srcset=\"https:\/\/my-immunity.com\/staging\/wp-content\/uploads\/2018\/06\/inonotus_obliquus-200x120.jpg 200w, https:\/\/my-immunity.com\/staging\/wp-content\/uploads\/2018\/06\/inonotus_obliquus-300x179.jpg 300w, https:\/\/my-immunity.com\/staging\/wp-content\/uploads\/2018\/06\/inonotus_obliquus.jpg 331w\" sizes=\"(max-width: 331px) 100vw, 331px\" \/><\/p>\n<p>Non abbiamo tradotto ma lasciato ogni pubblicazione scientifica sui funghi medicinale nella sua forma e lingua originale dal momento che tutte le informazioni provengono dal pi\u00f9 rinomato, antico e pi\u00f9 grande centro medico privato al mondo sul cancro, il <a href=\"http:\/\/www.mskcc.org\/cancer-care\/herb\/chaga-mushroom\" target=\"_blank\" rel=\"noopener\"><strong><span style=\"color: #008000;\">Memorial Sloan Kettering Cancer Center<\/span><\/strong><\/a>, che si trova a New York, fondato nel 1884.<\/p>\n<p><strong style=\"font-size: 18px;\"><span style=\"color: #008000;\">How It Works<\/span><\/strong><\/p>\n<p><strong>Bottom Line: Research is underway to determine the anticancer and immunostimulating effecs of chaga mushroom.<\/strong><\/p>\n<p>Chaga mushroom is found in Russia and has been used in traditional medicine. Studies show its constituents can kill cancer cells selectively and can stimulate the immune system. However, clinical trials are needed to verify chaga&#8217;s safety and effectiveness as a cancer treatment in humans.<\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Purported Uses<\/span><\/strong><\/span><\/div>\n<ul>\n<li><strong>To prevent and treat cancer<\/strong><br \/>\nPrevious studies have shown that chaga can inhibit the progression of certain cancers and activate subsets of immune cells. Research is in progress to study its anticancer effects in humans.<\/li>\n<li><strong>To stimulate the immune system<\/strong><br \/>\nChaga stimulated the activity of certain immune cells in laboratory-based experiments.<\/li>\n<li><strong>To reduce inflammation<\/strong><br \/>\nNo scientific evidence supports this use.<\/li>\n<li><strong>To protect the liver<\/strong><br \/>\nNo scientific evidence supports this use.<\/li>\n<\/ul>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Research Evidence<\/span><\/strong><\/span><\/div>\n<p>Chaga has been shown to aid in treatment of certain cancers. More studies are being conducted to confirm its effects as an anticancer agent in humans.<\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Do Not Take If<\/span><\/strong><\/span><\/div>\n<ul>\n<li>You are using a \u201cblood thinning\u201d drug.<\/li>\n<li>You are using medications to lower blood sugar (chaga may have additive effects).<\/li>\n<\/ul>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Side Effects<\/span><\/strong><\/span><\/div>\n<p>No side effects have been reported.<\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Clinical Summary<\/span><\/strong><\/span><\/div>\n<p>Chaga mushroom, found on Birch and other trees in cold climates, has been used in folk medicine in Russia and other North European countries for generations. Chaga draws nutrients from the tree on which it grows and extracts are typically derived from the inner layers of the bark. The active constituents are thought to be a combination of triterpenes, such as betulinic acid, sterols, and polysaccharides. Chaga has demonstrated anticancer, antiviral, antiplatelet <a class=\"ext\" href=\"#references-2\"><sup>(2)<\/sup><\/a>, anti-inflammatory, analgesic <a class=\"ext\" href=\"#references-3\"><sup>(3)<\/sup><\/a>, immune stimulating properties in vitro, and hypoglycemic effects in mice <a class=\"ext\" href=\"#references-4\"><sup>(4)<\/sup><\/a>. Chaga extract has inhibitory and proapoptotic effects against colon cancer <a class=\"ext\" href=\"#references-5\"><sup>(5)<\/sup><\/a> and hepatoma <a class=\"ext\" href=\"#references-1\"><sup>(1)<\/sup><\/a> cells. It also reduced toxicity associated with radiation <a class=\"ext\" href=\"#references-6\"><sup>(6)<\/sup><\/a> and inhibited tumor cell growth in animal models <a class=\"ext\" href=\"#references-7\"><sup>(7)<\/sup><\/a>. In some studies, Chaga demonstrates selective apoptosis in tumor cells with no effects on healthy cells <a class=\"ext\" href=\"#references-1\"><sup>(1)<\/sup><\/a>.<br \/>\nNo clinical trials have been conducted to assess chaga&#8217;s safety and efficacy for disease prevention or for the treatment of cancer, cardiovascular disease, or diabetes.<br \/>\nConstituents of chaga mushroom extract may interact with anticoagulant and antidiabetic drugs.<\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Food Sources<\/span><\/strong><\/span><\/div>\n<p>Although chaga is an edible fungus, it is not commonly ingested due to its bitter nature. Tea can be made from the whole mushroom.<\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Purported Uses<\/span><\/strong><\/span><\/div>\n<ul>\n<li>Antiviral<\/li>\n<li>Anti-inflammatory<\/li>\n<li>Antimutagenic<\/li>\n<li>Immunostimulation<\/li>\n<li>Cancer treatment<\/li>\n<li>Hepatoprotective<\/li>\n<\/ul>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Constituents<\/span><\/strong><\/span><\/div>\n<p><strong>Triterpenes<\/strong>: Inotodiol, Lanosterol, Ergosterol, Betulinic acid (Betulin) <a class=\"ext\" href=\"#references-10\"><sup>(10)<\/sup><\/a><\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Mechanism of Action<\/span><\/strong><\/span><\/div>\n<p>Chaga demonstrated hypoglycemic effects in mice with diabetes mellitus <a class=\"ext\" href=\"#references-4\"><sup>(4)<\/sup><\/a>. It&#8217;s anti-inflammatory and pain relieving properties are thought to be via inhibition of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) <a class=\"ext\" href=\"#references-3\"><sup>(3)<\/sup><\/a>. An extract of chaga reduced the oxidative stress in lymphocytes from patients with from inflammatory bowel disease <a class=\"ext\" href=\"#references-8\"><sup>(8)<\/sup><\/a>. Chaga also showed anti-mutagenic properties <a class=\"ext\" href=\"#references-9\"><sup>(9)<\/sup><\/a>. A hot water extract of chaga exhibited inhibitory and proapoptotic actions against colon cancer cell proliferation via up-regulation of Bax and caspase-3 and down-regulation of Bcl-2 <a class=\"ext\" href=\"#references-5\"><sup>(5)<\/sup><\/a>. Aqueous extracts of chaga also inhibited growth of human hepatoma cells via arrest of the cell cycle in Go\/G1 phase and inducing selective apoptosis <a class=\"ext\" href=\"#references-1\"><sup>(1)<\/sup><\/a>. The selectivity may also be a result of activation from a change in the pH of the tumor microenvironment <a class=\"ext\" href=\"#references-11\"><sup>(11)<\/sup><\/a>. Betulinic acid, a constituent of chaga, is cytotoxic and triggers apoptosis through a direct effect on the mitochondria of cancer cells. Other apoptosis-inducing factors result in cleavage of caspases and nuclear fragmentation <a class=\"ext\" href=\"#references-7\"><sup>(7)<\/sup><\/a>. Like many medicinal mushrooms, chaga is rich in beta glucans which have immunomodulating activities. Beta glucans bind to Complement Receptor 3 (CR3) that allows the immune cells to recognize cancer cells as \u201cnon-self\u201d <a class=\"ext\" href=\"#references-10\"><sup>(10)<\/sup><\/a>.<\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Adverse Reactions<\/span><\/strong><\/span><\/div>\n<p>None reported.<\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Herb-Drug Interactions<\/span><\/strong><\/span><\/div>\n<ul>\n<li><strong>Antiplatelet or anticoagulant drugs<\/strong>: Chaga extract can inhibit platelet aggregation <a class=\"ext\" href=\"#references-2\"><sup>(2)<\/sup><\/a>. It may also have additive anticoagulant effects.<\/li>\n<li><strong>Hypoglycemic agents<\/strong>: May have additive effect in lowering blood sugar levels.<\/li>\n<\/ul>\n<p><span style=\"color: #008000;\"><strong><u>Purpose of this published study is scientific information and education, it should not be used for diagnosing or treating a health problem or disease. This website is designed for general education and information purposes only and does not substitute for professional medical advice, examination, diagnosis or treatment.<\/u><\/strong><\/span><\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">References<\/span><\/strong><\/span><\/div>\n<p><span style=\"color: #008000;\"><em><strong>Source of Information: <a href=\"http:\/\/www.mskcc.org\/cancer-care\/herb\/chaga-mushroom\" target=\"_blank\" rel=\"noopener\">Memorial Sloan Kettering Cancer Center<\/a>, the oldest and largest private cancer center, located in New York, founded in 1884.<\/strong><\/em><\/span><\/p>\n<ol>\n<li>Youn MJ, Kim JK, Park SY, et al. <a name=\"references-1\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18203281\">Chaga mushroom (Inonotus obliquus) induces G0\/G1 arrest and apoptosis in human hepatoma HepG2 cells.<\/a> <em>World J Gastroenterol.<\/em> Jan 28 2008;14(4):511-517.<\/li>\n<li>Hyun KW, Jeong SC, Lee DH, Park JS, Lee JS. <a name=\"references-2\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16289471\">Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus.<\/a> <em>Peptides.<\/em> Jun 2006;27(6):1173-1178.<\/li>\n<li>Park YM, Won JH, Kim YH, et al. <a name=\"references-3\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15905055\">In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus.<\/a> <em>J Ethnopharmacol.<\/em> Oct 3 2005;101(1-3):120-128.<\/li>\n<li>Sun JE, Ao ZH, Lu ZM, et al. <a name=\"references-4\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18434051\">Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice.<\/a> <em>J Ethnopharmacol.<\/em> Jun 19 2008;118(1):7-13.<\/li>\n<li>Lee SH, Hwang HS, Yun JW. <a name=\"references-5\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19367670\">Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT-29 human colon cancer cells.<\/a> <em>Phytother Res.<\/em> Apr 15 2009.<\/li>\n<li>Zhong XH, Ren K, Lu SJ, Yang SY, Sun DZ. <a name=\"references-6\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19407959\">Progress of research on Inonotus obliquus.<\/a> <em>Chin J Integr Med.<\/em> Apr 2009;15(2):156-160.<\/li>\n<li>Youn MJ, Kim JK, Park SY, et al. <a name=\"references-7\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19041933\">Potential anticancer properties of the water extract of Inonotus [corrected] obliquus by induction of apoptosis in melanoma B16-F10 cells.<\/a> <em>J Ethnopharmacol.<\/em> Jan 21 2009;121(2):221-228.<\/li>\n<li>Najafzadeh M, Reynolds PD, Baumgartner A, Jerwood D, Anderson D. <a name=\"references-8\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18997282\">Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients with inflammatory bowel disease.<\/a> <em>Biofactors.<\/em> 2007;31(3-4):191-200.<\/li>\n<li>Ham SS, Kim SH, Moon SY, et al. <a name=\"references-9\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18992843\">Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract.<\/a> <em>Mutat Res.<\/em> Jan 10 2009;672(1):55-59.<\/li>\n<li>Caifa Chen WZ, Gao X, Xiang X, et al. <a name=\"references-10\"><\/a>Aqueous Extract of Inonotus obliquus (Fr.) Pilat (Hymenochaetaceae) Significantly Inhibits the Growth of Sarcoma 180 by Inducing Apoptosis. <em>Am J Pharmacol Toxicol.<\/em> 2007. 2(1):10-17.<\/li>\n<li>Shashkina MY, Shashkin PN, Sergeev AV. <a name=\"references-11\"><\/a>Chemical and Medicobiological Properties of Chaga (Review). <em>Pharmaceutical Chemistry Journal<\/em> 2006. 40(10):560-568.<\/li>\n<\/ol>\n<\/div>\n<\/div><\/div><\/div><div  class=\"fusion-layout-column fusion_builder_column fusion_builder_column_1_4  fusion-one-fourth fusion-column-last 1_4\"  style='margin-top: 0px;margin-bottom: 20px;width:25%;width:calc(25% - ( ( 4% ) * 0.25 ) );'><div class=\"fusion-column-wrapper\" style=\"padding: 0px 0px 0px 0px;background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\"  data-bg-url=\"\"><div class=\"fusion-widget-area fusion-widget-area-1 fusion-content-widget-area\"><style type=\"text\/css\" scoped=\"scoped\">.fusion-widget-area-1 {padding:0px 0px 0px 0px;}.fusion-widget-area-1 .widget h4 {color:#333333;}.fusion-widget-area-1 .widget .heading h4 {color:#333333;}<\/style>\n\t\t<section id=\"recent-posts-2\" class=\"widget widget_recent_entries\">\n\t\t<div class=\"heading\"><h4 class=\"widget-title\">\u0421\u043a\u043e\u0440\u0430\u0448\u045a\u0438 \u0447\u043b\u0430\u043d\u0446\u0438<\/h4><\/div>\n\t\t<ul>\n\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t<a href=\"https:\/\/my-immunity.com\/staging\/immunotherapy.html\">Immunotherapy &#8211; the next generation of cancer treatment<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t<a href=\"https:\/\/my-immunity.com\/staging\/es\/cu%c3%a1les-son-los-componentes-del-sistema-inmune.html\">\u00bfCu\u00e1les son los componentes del sistema inmune?<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t<a href=\"https:\/\/my-immunity.com\/staging\/es\/atp-molecula-que-lleva-la-energia-de-la-vida.html\">ATP mol\u00e9cula que lleva la &#8222;energ\u00eda de la vida&#8220;<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t<a href=\"https:\/\/my-immunity.com\/staging\/ru\/%d1%87%d1%82%d0%be-%d1%82%d0%b0%d0%ba%d0%be%d0%b5-%d0%bc%d0%b5%d0%b4%d0%b8%d1%86%d0%b8%d0%bd%d1%81%d0%ba%d0%b8%d0%b5-%d0%b3%d1%80%d0%b8%d0%b1%d1%8b.html\">\u0427\u0442\u043e \u0442\u0430\u043a\u043e\u0435 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0435 \u0433\u0440\u0438\u0431\u044b<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t<a href=\"https:\/\/my-immunity.com\/staging\/ru\/%d0%ba%d0%b0%d0%ba-%d0%bf%d1%80%d0%be%d0%b8%d1%81%d1%85%d0%be%d0%b4%d0%b8%d1%82-%d0%b1%d0%be%d0%bb%d0%b5%d0%b7%d0%bd%d1%8c.html\">\u041a\u0430\u043a \u043f\u0440\u043e\u0438\u0441\u0445\u043e\u0434\u0438\u0442 \u0431\u043e\u043b\u0435\u0437\u043d\u044c<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t<\/ul>\n\n\t\t<\/section><section id=\"text-2\" class=\"widget widget_text\" style=\"border-style: solid;border-color:transparent;border-width:0px;\">\t\t\t<div class=\"textwidget\"><p>Aloha Medicinals proizvode mo\u017eete poru\u010diti putem pouze\u0107a na:<\/p>\n<p>tel: <strong>011\/ 25 46 452 i 062\/ 55 77 12<\/strong><\/p>\n<p>Tro\u0161kove dostave pla\u0107amo mi, osim kod ponude 3+1 gratis, gde tro\u0161kove dostave pla\u0107a kupac.<\/p>\n<p><strong>MOJ IMUNITET D.O.O. 11000 Beograd Tel: 011\/ 25 46 452 i 062\/ 55 77 12<\/strong><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n\t\t<\/section><div class=\"fusion-additional-widget-content\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div>\n\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.8 - 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