{"id":1519,"date":"2018-07-04T01:05:13","date_gmt":"2018-07-03T23:05:13","guid":{"rendered":"https:\/\/my-immunity.com\/staging\/?page_id=1519"},"modified":"2018-07-04T14:00:02","modified_gmt":"2018-07-04T12:00:02","slug":"grifola-frondosa-it","status":"publish","type":"page","link":"https:\/\/my-immunity.com\/staging\/it\/grifola-frondosa-it.html","title":{"rendered":"Grifola Frondosa IT"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\"  style='background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;'><div class=\"fusion-builder-row fusion-row \"><div  class=\"fusion-layout-column fusion_builder_column fusion_builder_column_1_1  fusion-one-full fusion-column-first fusion-column-last 1_1\"  style='margin-top:0px;margin-bottom:20px;'>\n\t\t\t\t\t<div class=\"fusion-column-wrapper\" style=\"padding: 0px 0px 0px 0px;background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\"  data-bg-url=\"\">\n\t\t\t\t\t\t<div class=\"fusion-builder-row fusion-builder-row-inner fusion-row \"><div  class=\"fusion-layout-column fusion_builder_column fusion_builder_column_3_4  fusion-three-fourth fusion-column-first 3_4\"  style='margin-top: 0px;margin-bottom: 20px;width:75%;width:calc(75% - ( ( 4% ) * 0.75 ) );margin-right:4%;'><div class=\"fusion-column-wrapper\" style=\"padding: 0px 0px 0px 0px;background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;\"  data-bg-url=\"\"><div class=\"fusion-text\"><div class=\"content-story clear-block\">\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Maitake<\/span><\/strong><\/span><\/div>\n<p><strong>Scientific Name:<\/strong> Grifola frondosa<\/p>\n<p><strong>Common Name:<\/strong> King of mushrooms, dancing mushroom, cloud mushroom, hen of woods<\/p>\n<p><img decoding=\"async\" class=\"aligncenter size-full wp-image-1271\" src=\"https:\/\/my-immunity.com\/staging\/wp-content\/uploads\/2018\/06\/grifola_frondosa.jpg\" alt=\"grifola_frondosa\" width=\"331\" height=\"198\" srcset=\"https:\/\/my-immunity.com\/staging\/wp-content\/uploads\/2018\/06\/grifola_frondosa-200x120.jpg 200w, https:\/\/my-immunity.com\/staging\/wp-content\/uploads\/2018\/06\/grifola_frondosa-300x179.jpg 300w, https:\/\/my-immunity.com\/staging\/wp-content\/uploads\/2018\/06\/grifola_frondosa.jpg 331w\" sizes=\"(max-width: 331px) 100vw, 331px\" \/><\/p>\n<p>Non abbiamo tradotto ma lasciato ogni pubblicazione scientifica sui funghi medicinale nella sua forma e lingua originale dal momento che tutte le informazioni provengono dal pi\u00f9 rinomato, antico e pi\u00f9 grande centro medico privato al mondo sul cancro, il <a href=\"http:\/\/www.mskcc.org\/cancer-care\/herb\/maitake\" target=\"_blank\" rel=\"noopener\"><strong><span style=\"color: #008000;\">Memorial Sloan Kettering Cancer Center<\/span><\/strong><\/a>, che si trova a New York, fondato nel 1884.<\/p>\n<p><strong style=\"font-size: 18px;\"><span style=\"color: #008000;\">How It Works<\/span><\/strong><\/p>\n<p><strong>Bottom Line: Maitake demonstrated anticancer effects in laboratory studies. Research is underway to test its anticancer effects in humans.<\/strong><\/p>\n<p>Maitake is a mushroom that traditionally has been used in Japan and China as part of the diet and to treat diabetes and hypertension. Like other medicinal mushrooms, maitake contains a complex sugar called a beta-glucan. In laboratory studies, maitake extract was able to stimulate various cells and factors in the immune system. Studies in animals show that it slows the growth of certain tumors and lowers blood glucose (sugar) levels. More studies are being conducted to determine if maitake has the same effects in humans.<\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Purported Uses<\/span><\/strong><\/span><\/div>\n<ul>\n<li><strong>To prevent and treat cancer<\/strong><br \/>\nLaboratory studies and small uncontrolled studies in humans show that maitake extracts slow the growth of tumors and stimulate certain immune cells.<\/li>\n<li><strong>To manage diabetes<\/strong><br \/>\nitake reduces blood glucose levels in rats.<\/li>\n<li><strong>To lower high cholesterol<\/strong><br \/>\nNo scientific evidence supports this use.<\/li>\n<li><strong>To lower high blood pressure<\/strong><br \/>\nThere are no studies to support this claim.<\/li>\n<li><strong>As an immune stimulant<\/strong><br \/>\naitake stimulates the activity of certain immune cells in laboratory studies and in mice.<\/li>\n<li><strong>To lose weight<\/strong><br \/>\nThis claim is not backed by research.<\/li>\n<\/ul>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Do Not Take If<\/span><\/strong><\/span><\/div>\n<ul>\n<li>You are taking <strong>hypoglycemic medications<\/strong> to lower your blood sugar, as maitake can increase their effects.<\/li>\n<li>You are taking <strong>warfarin<\/strong>, as maitake may interact with warfarin resulting in an elevated international normalized ratio (INR).<\/li>\n<\/ul>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Clinical Summary<\/span><\/strong><\/span><\/div>\n<p>Maitake mushroom is an edible mushroom consumed widely in Asia as food and used in traditional medicine to treat diabetes and hypertension. Maitake extracts are commercially available as dietary supplements marketed to \u201cenhance immune function\u201d and to treat HIV and cancer. Beta 1,6-glucan, a protein bound polysaccharide, has been identified as the active constituent.<\/p>\n<p>Maitake extracts exhibited hypoglycemic effects in a few studies <a class=\"ext\" href=\"#references-9\"><sup>(9)<\/sup><\/a> <a class=\"ext\" href=\"#references-12\"><sup>(12)<\/sup><\/a>. Preliminary data suggest that maitake may be useful in inducing ovulation in patients with polycystic ovary syndrome (PCOS) <a class=\"ext\" href=\"#references-22\"><sup>(22)<\/sup><\/a>.<\/p>\n<p>Maitake demonstrated antitumor effects <a class=\"ext\" href=\"#references-16\"><sup>(16)<\/sup><\/a>, enhanced bone marrow colony formation, reduced doxorubicin toxicity <a class=\"ext\" href=\"#references-11\"><sup>(11)<\/sup><\/a>, and inhibited tumor metastasis in vitro <a class=\"ext\" href=\"#references-13\"><sup>(13)<\/sup><\/a>. In a study done in mice, oral maitake extract promoted maturation of hematopoietic cells to functionally active myeloid cells and enhanced peripheral blood leukocyte recovery following chemotoxic bone marrow injury <a class=\"ext\" href=\"#references-17\"><sup>(17)<\/sup><\/a>. A novel polysaccharide, MZF, was shown to induce dendritic cell maturation and enhanced antitumor response <a class=\"ext\" href=\"#references-20\"><sup>(20)<\/sup><\/a>.<br \/>\nMaitake also enhanced interferon activity against bladder cancer cells <a class=\"ext\" href=\"#references-18\"><sup>(18)<\/sup><\/a> and alleviated inflammation associated with inflammatory bowel disease <a class=\"ext\" href=\"#references-19\"><sup>(19)<\/sup><\/a>.<br \/>\nIn a small non-controlled study, tumor regression or significant improvements in symptoms were observed in half of the subjects using Maitake extract <a class=\"ext\" href=\"#references-5\"><sup>(5)<\/sup><\/a>. In another study of postmenopausal breast cancer patients, oral administration of maitake extract was shown to have immunomodulatory effects <a class=\"ext\" href=\"#references-14\"><sup>(14)<\/sup><\/a>.<br \/>\nMore studies are underway to establish Maitake&#8217;s anticancer potential.<\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Food Sources<\/span><\/strong><\/span><\/div>\n<p>Maitake mushroom is an edible fungus. The whole mushroom can be fried or boiled.<\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Purported Uses<\/span><\/strong><\/span><\/div>\n<ul>\n<li>Cancer prevention<\/li>\n<li>Diabetes<\/li>\n<li>High cholesterol<\/li>\n<li>Hypertension<\/li>\n<li>Immunostimulation<\/li>\n<li>Weight loss<\/li>\n<\/ul>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Constituents<\/span><\/strong><\/span><\/div>\n<ul>\n<li>Polysaccharides: 1,3 and 1,6 beta-glucans appear to be the most active ingredients. Alpha glucan is also present.<\/li>\n<li>Lipids: Octadecanoic and octadecadienoic acids<\/li>\n<li>Phospholipids: Phosphatidylethanolamine, phosphatidylcholine, phosphatidylinositol, phosphatidylserine and phosphatidic acid<\/li>\n<li>Ergosterol (vitamin D2)<\/li>\n<\/ul>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Mechanism of Action<\/span><\/strong><\/span><\/div>\n<p>Maitake is thought to exert its effects through its ability to activate various effector cells, such as macrophages, natural killer cells, and T cells, as well as interleukin-1 and superoxide anions <a class=\"ext\" href=\"#references-2\"><sup>(2)<\/sup><\/a> <a class=\"ext\" href=\"#references-3\"><sup>(3)<\/sup><\/a> <a class=\"ext\" href=\"#references-4\"><sup>(4)<\/sup><\/a> <a class=\"ext\" href=\"#references-13\"><sup>(13)<\/sup><\/a>. Studies also suggest possible hypoglycemic activity <a class=\"ext\" href=\"#references-9\"><sup>(9)<\/sup><\/a>. The anti-diabetic effect of alpha-glucan may be due to its effects on insulin receptors by increasing insulin sensitivity and ameliorating insulin resistance of peripheral target tissues <a class=\"ext\" href=\"#references-12\"><sup>(12)<\/sup><\/a>.<br \/>\nMaitake extract enhanced the growth and differentiation of mouse bone marrow cells treated with doxorubicin, a chemotherapeutic agent <a class=\"ext\" href=\"#references-11\"><sup>(11)<\/sup><\/a>. In addition, maitake extract may modulate antigen presentation as evidenced by protection of mice against tumor implantation following transfer of dendritic cells from tumor-bearing mice that were treated with maitake extract <a class=\"ext\" href=\"#references-15\"><sup>(15)<\/sup><\/a>.<br \/>\nMaitake D fraction demonstrated antitumor activity by upregulating expression of a proapoptotic gene, BAK-1 <a class=\"ext\" href=\"#references-23\"><sup>(23)<\/sup><\/a>. In another study the beta glucan GFPBW1 also showed antitumor effects thought partially due to activation of macrophages via the Dectin-1\/Syk\/NF-\u03baB signaling pathway <a class=\"ext\" href=\"#references-24\"><sup>(24)<\/sup><\/a>.<\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Contraindications<\/span><\/strong><\/span><\/div>\n<p>Maitake may not be appropriate for those taking hypoglycemic medications as it can have synergistic effects <a class=\"ext\" href=\"#references-9\"><sup>(9)<\/sup><\/a>.<\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Herb-Drug Interactions<\/span><\/strong><\/span><\/div>\n<p>Warfarin: Maitake may interact with warfarin resulting in an elevated international normalized ratio (INR).<\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">Herb Lab Interactions<\/span><\/strong><\/span><\/div>\n<p>May lower blood glucose level.<\/p>\n<p><span style=\"color: #008000;\"><strong><u>Purpose of this published study is scientific information and education, it should not be used for diagnosing or treating a health problem or disease. This website is designed for general education and information purposes only and does not substitute for professional medical advice, examination, diagnosis or treatment.<\/u><\/strong><\/span><\/p>\n<div><span style=\"font-size: 18px;\"><strong><span style=\"color: #008000;\">References<\/span><\/strong><\/span><\/div>\n<p><span style=\"color: #008000;\"><em><strong>Source of Information: <a href=\"http:\/\/www.mskcc.org\/cancer-care\/herb\/maitake\" target=\"_blank\" rel=\"noopener\">Memorial Sloan Kettering Cancer Center<\/a>, the oldest and largest private cancer center, located in New York, founded in 1884.<\/strong><\/em><\/span><\/p>\n<ol>\n<li>Hobbs C. Medicinal Mushrooms, <a name=\"references-1\"><\/a>3rd ed. Loveland (CO): Interweave Press; 1996.<\/li>\n<li>Adachi K, Nanba H, Kuroda H. <a name=\"references-2\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3594655\">Potentiation of host-mediated antitumor activity in mice by beta glucan obtained from Grifola frondosa (maitake).<\/a> <em>Chem Pharm Bull<\/em> 1987;35:262-70.<\/li>\n<li>Kubo K, Aoki H. Nanba H. <a name=\"references-3\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7820117\">Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake).<\/a> <em>Biol Pharm Bull<\/em> 1994;17:1106-10.<\/li>\n<li>Horio H, Ohtsuru M. <a name=\"references-4\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11349892\">Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats.<\/a> <em>J Nutr Sci Vitaminol<\/em> 2001;47:57-63.<\/li>\n<li>Kodama N, Komuta K, Nanba H. <a name=\"references-5\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12126464\">Can Maitake MD-fraction aid cancer patients?<\/a> <em>Altern Med Rev<\/em> 2002;7:236-9.<\/li>\n<li>Miura NN. <a name=\"references-6\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8821398\">Blood clearance of (1\u2014&gt;3)-beta-D-glucan in MRL <em>lpr\/lpr<\/em> mice.<\/a> <em>FEMS Immunol Med<\/em> <em>Microbiol<\/em> 1996;13:51-7.<\/li>\n<li>Ohno N, et al. <a name=\"references-7\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3719872\">Characterization of the antitumor glucan obtained from liquid-cultured Grifola frondosa.<\/a> <em>Chem Pharm Bull<\/em> 1986;34:1709-1715.<\/li>\n<li>Nanba H, Kubo K. <a name=\"references-8\"><\/a>Maitake D-fraction: Healing and preventive potential for cancer. <em>J Orthomolecular Med<\/em> 1997;12:43-9.<\/li>\n<li>Konno S, et al. <a name=\"references-9\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11903406\">A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients.<\/a> <em>Diabet Med<\/em> 2001 Dec;18(12):1010<\/li>\n<li>Yamada Y, et al. <a name=\"references-10\"><\/a>Antitumor effect of orally administered extracts from fruit body of grifola frondosa (maitake). <em>Chemotherapy<\/em> 1990;38:790-6.<\/li>\n<li>Lin H, et al. <a name=\"references-11\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14975363\">Maitake beta-glucan MD-fraction enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro.<\/a> <em>Int Immunopharmacol<\/em> 2004 Jan;4(1):91-9.<\/li>\n<li>Hong L, Xun M, Wutong W. <a name=\"references-12\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17430642\">Anti-diabetic effect of an alpha-glucan from fruit body of maitake (Grifola frondosa) on KK-Ay mice.<\/a> <em>Pharm Pharmacol<\/em>. 2007 Apr;59(4):575-82.<\/li>\n<li>Masuda Y, Murata Y, Hayashi M, Nanba H. <a name=\"references-13\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18520039\">Inhibitory effect of MD-Fraction on tumor metastasis: involvement of NK cell activation and suppression of intercellular adhesion molecule (ICAM)-1 expression in lung vascular endothelial cells.<\/a> <em>Biol Pharm Bull<\/em> 2008 Jun;31(6):1104-8.<\/li>\n<li>Deng G, Lin H, Seidman A, et al. <a name=\"references-14\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19253021\">A phase I\/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects.<\/a> <em>J Cancer Res Clin Oncol. <\/em>2009 Sep;135(9):1215-21<\/li>\n<li>Harada N, Kodama N, Nanba H. <a name=\"references-15\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12668282\">Relationship between dendritic cells and the D-fraction-induced Th-1 dominant response in BALB\/c tumor-bearing mice.<\/a> <em>Cancer Lett.<\/em> 2003;192(2):181-7.<\/li>\n<li>Shomori K, Yamamoto M, Arifuku I, Teramachi K, Ito H. <a name=\"references-16\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19639212\">Antitumor effects of a water-soluble extract from Maitake (Grifola frondosa) on human gastric cancer cell lines.<\/a> <em>Oncol Rep.<\/em> 2009 Sep;22(3):615-20.<\/li>\n<li>Lin H, de Stanchina E, Zhou XK, et al. <a name=\"references-17\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20140432\">Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity.<\/a> <em>Cancer Immunol Immunother.<\/em> 2010 Jun;59(6):885-97.<\/li>\n<li>Louie B, Rajamahanty S, Won J, Choudhury M, Konno S. <a name=\"references-18\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19735256\">Synergistic potentiation of interferon activity with maitake mushroom d-fraction on bladder cancer cells.<\/a> <em>BJU Int.<\/em> 2010 Apr;105(7):1011-5.<\/li>\n<li>Lee JS, Park SY, Thapa D, et al. <a name=\"references-19\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20054232\">Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling.<\/a> <em>Exp Mol Med.<\/em> 2010 Feb 28;42(2):143-54.<\/li>\n<li>Masuda Y, Ito K, Konishi M, Nanba H. <a name=\"references-20\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20563803\">A polysaccharide extracted from Grifola frondosa enhances the anti-tumor activity of bone marrow-derived dendritic cell-based immunotherapy against murine colon cancer.<\/a> <em>Cancer Immunol Immunother.<\/em> 2010 Oct;59(10):1531-41.<\/li>\n<li>Hanselin MR, Vande Griend JP, Linnebur SA. <a name=\"references-21\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20040699\">INR elevation with maitake extract in combination with warfarin.<\/a> <em>Ann Pharmacother.<\/em> 2010 Jan;44(1):223-4.<\/li>\n<li>Chen JT, Tominaga K, Sato Y, Anzai H, Matsuoka R. <a name=\"references-22\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21034160\">Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate.<\/a> <em>J Altern Complement Med.<\/em> 2010 Dec;16(12):1295-9.<\/li>\n<li>Soares R, Meireles M, Rocha A, et al. <a name=\"references-23\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21480800\">Maitake (D fraction) mushroom extract induces apoptosis in breast cancer cells by BAK-1 gene activation.<\/a><em>J Med Food.<\/em> 2011 Jun;14(6):563-72.<\/li>\n<li>Fang J, Wang Y, Lv X, et al. <a name=\"references-24\"><\/a><a class=\"ext\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22744837\">Structure of a \u03b2-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1\/Syk\/NF-\u03baB signaling.<\/a> <em>Glycoconj J. <\/em>2012 Aug;29(5-6):365-77.<\/li>\n<\/ol>\n<p><a href=\"#top\">Top<\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><div  class=\"fusion-layout-column fusion_builder_column fusion_builder_column_1_4  fusion-one-fourth fusion-column-last 1_4\"  style='margin-top: 0px;margin-bottom: 20px;width:25%;width:calc(25% - ( ( 4% ) * 0.25 ) );'><div 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class=\"fusion-additional-widget-content\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-clearfix\"><\/div>\n\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Grifola Frondosa IT - My immunity<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/my-immunity.com\/staging\/it\/grifola-frondosa-it.html\" \/>\n<meta property=\"og:locale\" content=\"sr_RS\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Grifola Frondosa IT - My immunity\" \/>\n<meta property=\"og:url\" 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