{"id":1392,"date":"2018-07-02T21:38:47","date_gmt":"2018-07-02T19:38:47","guid":{"rendered":"https:\/\/my-immunity.com\/staging\/?page_id=1392"},"modified":"2019-08-29T00:25:46","modified_gmt":"2019-08-28T22:25:46","slug":"gli-studi-clinici","status":"publish","type":"page","link":"https:\/\/my-immunity.com\/staging\/it\/gli-studi-clinici.html","title":{"rendered":"GLI STUDI CLINICI"},"content":{"rendered":"
\n\t\t\t\t\t
\n\t\t\t\t\t\t
\n
\n
\n
ESONERO DI RESPONSABILITA\u2019<\/div>\n
<\/div>\n

Questo sito web \u00e8 studiato con il solo obiettivo di fornire formazione e informazione e non sostituisce alcun consiglio, esame, diagnosi o trattamento medico. Le informazioni fornite attraverso questo sito non devono essere utilizzate per diagnosi o trattamento di alcun problema di salute o patologia. Non sostituisce gli operatori professionali della salute ed \u00e8 studiato per supportare e non sostituire il vostro medico.<\/strong><\/p>\n

\"\" \"\" \"\"<\/p>\n

<\/div>\n

In the world’s largest electronic medical database maintained by the U.S. government, „MEDLINE“ <\/a><\/strong><\/span>in 2013 there<\/span> were 115 scientific articles on \u00a0topic\u00a0„<\/strong>Medicinal <\/strong>Mushrooms<\/strong>and Cancer<\/strong>„<\/strong><\/a><\/strong>,<\/strong> 489 articles\u00a0 on \u00a0topic\u00a0 „Medicinal mushrooms“<\/strong><\/a>. <\/strong>Number of\u00a0 scientific articles published on \u00a0most popular medicinal mushrooms:\u00a0 <\/strong>Ganoderma Lucidum\u00a0 <\/strong><\/a>(Reishi) 921, Coriolus Versicolor<\/strong><\/a> 302, Cordyceps Sinensis <\/strong><\/a>807,\u00a0 Agaricus Blazei<\/strong><\/a> 211,\u00a0 Lentinula Edodes<\/strong><\/a> (Shiitake) 502, Grifola Frondosa<\/strong><\/a> (Maitake) 244<\/strong><\/p>\n

\"\" \"\" \"\"<\/p>\n

\n

Clinical Trials:<\/b><\/h3>\n

Reducing the side effects: Using\u00a0Immune Assist (K9 Immunity)<\/i>\u00a0<\/b>in Cancer treatment to reduce side effects:\u00a0Cancer Clinical Trial<\/a>\u00a0\u00a0<\/b>(web page)<\/p>\n

Immune Assist<\/i><\/b>\u00a0is the human grade, the same product in veterinary packaging is named\u00a0K9 Immunity<\/i><\/b><\/p>\n

[PDF] Hybridization of Cordyceps sinensis and Quality Analysis – An article on Aloha Medicinals Cordyceps from the „International Journal of Medicinal Mushrooms<\/em>„<\/a><\/p>\n

[PDF] On The Trail of the Yak – Most complhttps:\/\/www.moj-imunitet.com\/wp-content\/uploads\/2019\/08\/Hybridization-of-Cordyceps-sinensis.pdfete article yet on Cordyceps<\/a><\/p>\n

[PDF] Immuno-modulating and Anti-tumor compounds from Medicinal Mushrooms by Dr. Solomon Wasser – Great Article!<\/a><\/p>\n

[PDF] Medicinal Properties of Substances Occuring in Higher Basidiomycetes Mushrooms: Current Perspective (Review) by Dr. Solomon Wasser – Another Great Article!<\/a><\/p>\n

Medicinal Mushrooms<\/a><\/p>\n

Official Government Publication: <\/b><\/span><\/span><\/p>\n

Cancer Research UK<\/a>: Medicinal Mushrooms: Their therapeutic properties and current medical usage with special emphasis on cancer treatments:<\/a><\/strong><\/h3>\n

by Richard Sullivan MD PhD\u00a0\u00a0 <\/em><\/span><\/a>Dr.<\/em>Richard Sullivan<\/em> is Professor<\/em> of Cancer Policy & Global Health at Kings College<\/em> London and Director of the new Kings Institute of Cancer Policy.<\/span><\/span><\/strong><\/p>\n

Table of Contents<\/a>\u00a0(PDF 8.87 kb)<\/p>\n

Preamble<\/a>\u00a0(PDF 15.5 kb)<\/p>\n

Chapter 1<\/a>\u00a0– Introduction (PDF 36.3 kb)<\/p>\n

Chapter 2<\/a>\u00a0– The Nature of Fungi with Special Emphasis on Mushrooms\u00a0 (PDF 1.41 Mb)<\/p>\n

Chapter 3a<\/a>\u00a0– Medicinally Important Mushrooms Part 1 (PDF 8.12 Mb)<\/p>\n

Chapter 3b<\/a>\u00a0– Medicinally Important Mushrooms Part 2 (PDF 8.75 Mb)<\/p>\n

Chapter 3c<\/a>\u00a0– Medicinally Important Mushrooms Part 3 (PDF 8.33 Mb)<\/p>\n

Chapter 4<\/a>\u00a0– Technology of Mushroom Cultivation (PDF 338 kb)<\/p>\n

Chapter 5<\/a>\u00a0– Extraction, Development and Chemistry of Anti-Cancer Compounds from Medicinal Mushrooms (PDF 399 kb)<\/p>\n

Chapter 6<\/a>\u00a0– Immunomodulatory Activities of Mushroom GlucansPolysaccharide-Protein Complexes in Animals and Humans (PDF 216 kb)<\/p>\n

Chapter 7<\/a>\u00a0– The Role of Polysaccharides Derived from Medicinal Mushrooms in Cancer (PDF 133 kb)<\/p>\n

Chapter 8\u00a0<\/a>– Additional Medicinal Properties (PDF 84.2 kb)<\/p>\n

Chapter 9<\/a>\u00a0– Regulatory and Safety Criteria (PDF 67.8 kb)<\/p>\n

Chapter 10<\/a>\u00a0– Conclusions(PDF 49.5 kb)<\/p>\n

Appendix 1<\/a>\u00a0– Overview of Human Immune System (PDF 603 kb)<\/p>\n

Appendix 2<\/a>\u00a0– Standard Antitumor Activity Test (PDF 12.7 kb)<\/p>\n

Appendix 3<\/a>\u00a0– Medicinal Mushrooms and Cancer Prevention (PDF 17.0 kb)<\/p>\n

Author Biographies<\/a>\u00a0(PDF 21.6 kb)<\/p>\n

Executive Summary<\/a>\u00a0(PDF 32.7 kb)<\/p>\n

Acknowledgment<\/a>\u00a0(PDF 6.89 kb)<\/p>\n

Front Cover<\/a>\u00a0(JPG 69 kb)<\/p>\n

Back Cover<\/a>\u00a0(JPG 26.29 kb)<\/p>\n<\/div>\n

\n

Memorial Sloan<\/em>\u2013Kettering Cancer Center (MSKCC)- Founded in 1884 as the New York Cancer Hospital, Memorial Sloan<\/em>–Kettering Cancer Center<\/em> (MSKCC<\/em>) is one of the oldest cancer centers in the country.<\/span><\/span><\/a><\/strong><\/span><\/h3>\n

References:<\/p>\n

Cordyceps Sinensis:<\/p>\n

\n
\n
    \n
  1. Huang KC. The Pharmacology of Chinese Herbs, 2nd<\/sup> ed. Boca Raton: CRC Press; 1999.<\/li>\n
  2. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regime: Cordyceps sinensis, Part I<\/a>. J Altern Complement Med<\/em> 1998;4:289-303.<\/li>\n
  3. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regime: Cordyceps sinensis, Part II<\/a>. J Altern Complement Med<\/em> 1998;4:429-57.<\/li>\n
  4. Xu F, et al. Amelioration of cyclosporin nephrotoxicity by Cordyceps sinensis in kidney-transplant recipients<\/a>. Nephrol Dial Transplant<\/em> 1995;10:142-3.<\/li>\n
  5. Huang B, et al. Cordyceps sinensis and its fractions stimulate MA-10 mouse Leydig tumor cell steroidogenesis<\/a>. J Androl<\/em> 2001;22:831-7.<\/li>\n
  6. Nakamura K, et al. Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice<\/a>. Jpn J Pharmacol<\/em> 1999;79:335-41.<\/li>\n
  7. Chiu JH, et al. Cordyceps sinensis increases the expression of major histocompatibility complex class II antigens in human hepatoma cell line HA22T\/VGH cells<\/a>. Am J Chin Med<\/em> 1998;26:59-70.<\/li>\n
  8. Li, Y. et. al. Effect of Cordyceps sinensis on erythropoiesis in mouse bone marrow<\/a>. Chin Med J (Engl)<\/em>. 1993 Apr;106(4):313-6.<\/li>\n
  9. Huang YL, Leu SF, Liu BC, et al. In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse.<\/a> Life Sci<\/em> 2004 Jul 16;75(9):1051-62.<\/li>\n
  10. Wu WC, Hsiao JR, Lian YY, et al. The apoptotic effect of cordycepin on human OEC-M1 oral cancer cell line.<\/a> Cancer Chemother Pharmacol.<\/em> 2007 Jun;60(1):103-11.<\/li>\n
  11. Oh JY, Baek YM, Kim SW, et al. Apoptosis of human hepatocarcinoma (HepG2) and neuroblastoma (SKN-SH) cells induced by polysaccharides-peptide complexes produced by submerged mycelial culture of an entomopathogenic fungus Cordyceps sphecocephala.<\/a> J Microbiol Biotechnol.<\/em> 2008 Mar;18(3):512-9.<\/li>\n
  12. Liu WC, Wang SC, Tsai ML, et al. Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine.<\/a> Radiat Res.<\/em> 2006 Dec;166(6):900-7.<\/li>\n
  13. Liu WC, Chuang WL, Tsai ML, et al. Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia.<\/a> Exp Biol Med (Maywood).<\/em> 2008 Apr;233(4):447-55.<\/li>\n
  14. Kubo E, Yoshikawa N, Kunitomo M, et al. Inhibitory effect of Cordyceps sinensis on experimental hepatic metastasis of melanoma by suppressing tumor cell invasion.<\/a> Anticancer Res.<\/em> 2010 Sep;30(9):3429-33.<\/li>\n
  15. Lo HC, Hsu TH, Tu ST, Lin KC. Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin.<\/a> Am J Chin Med.<\/em> 2006;34(5):819-32.<\/li>\n
  16. Shi B, Wang Z, Jin H, et al. Immunoregulatory Cordyceps sinensis increases regulatory T cells to Th17 cell ratio and delays diabetes in NOD mice.<\/a> Int Immunopharmacol.<\/em> 2009 May;9(5):582-6.<\/li>\n
  17. Ji NF, Yao LS, Li Y, et al. Polysaccharide of Cordyceps sinensis Enhances Cisplatin Cytotoxicity in Non-Small Cell Lung Cancer H157 Cell Line.<\/a> Integr Cancer Ther.<\/em> 2011;10(4):359-67.<\/li>\n
  18. Zhang Z, Wang X, Zhang Y, Ye G. Effect of Cordyceps sinensis on Renal Function of Patients with Chronic Allograft Nephropathy.<\/a> Urol Int.<\/em> 2011;86(3):298-301.<\/li>\n<\/ol>\n

    <\/h3>\n<\/div>\n<\/div>\n<\/div>\n
    \n
    \n
    \n
    \n
    \n

    Agaricus Blazei <\/strong><\/h3>\n
      \n
    1. \n
      \n
      \n
      \n
        \n
      1. Fujimiya Y, Suzuki Y, Oshiman K, et al. Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis.<\/a> Cancer Immunol Immunother.<\/em> May 1998;46(3):147-159.<\/li>\n
      2. Itoh H, Ito H, Amano H, et al. Inhibitory action of a (1\u2014>6)-beta-D-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murill (\u201chimematsutake\u201d) on Meth A fibrosarcoma-bearing mice and its antitumor mechanism.<\/a> Jpn J Pharmacol.<\/em> Oct 1994;66(2):265-271.<\/li>\n
      3. Kimura Y, Kido T, Takaku T, et al. Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions.<\/a> Cancer Sci.<\/em> Sep 2004;95(9):758-764.<\/li>\n
      4. Lee YL, Kim HJ, Lee MS, et al. Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model.<\/a> Exp Anim.<\/em> Oct 2003;52(5):371-375.<\/li>\n
      5. Mizuno M, Morimoto M, Minato K, et al. Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice.<\/a> Biosci Biotechnol Biochem.<\/em> Mar 1998;62(3):434-437.<\/li>\n
      6. Takaku T, Kimura Y, Okuda H. Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action.<\/a> J Nutr.<\/em> May 2001;131(5):1409-1413.<\/li>\n
      7. Ahn WS, Kim DJ, Chae GT, et al. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy.<\/a> Int J Gynecol Cancer.<\/em> Jul-Aug 2004;14(4):589-594.<\/li>\n
      8. Gray AM, Flatt PR. Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom).<\/a> J Endocrinol.<\/em> May 1998;157(2):259-266.<\/li>\n
      9. Swanston-Flatt SK, Day C, Flatt PR, et al. Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice.<\/a> Diabetes Res.<\/em> Feb 1989;10(2):69-73.<\/li>\n
      10. Kim YW, Kim KH, Choi HJ, et al. Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei.<\/a> Biotechnol Lett.<\/em> Apr 2005;27(7):483-487.<\/li>\n
      11. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial.<\/a> J Altern Complement Med.<\/em> Jan-Feb 2007;13(1):97-102.<\/li>\n
      12. Liu Y, Fukuwatari Y, Okumura K, et al. Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers.<\/a> Evid Based Complement Alternat Med.<\/em> Jun 2008;5(2):205-219.<\/li>\n
      13. Hsu CH, Hwang KC, Chiang YH, et al. The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B.<\/a> J Altern Complement Med.<\/em> Apr 2008;14(3):299-301.<\/li>\n
      14. Mukai H, Watanabe T, Ando M, et al. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients.<\/a> Jpn J Clin Oncol.<\/em> Dec 2006;36(12):808-810.<\/li>\n
      15. Suehiro M, Katoh N, Kishimoto S. Cheilitis due to Agaricus blazei Murill mushroom extract.<\/a> Contact Dermatitis.<\/em> May 2007;56(5):293-294.<\/li>\n
      16. Dong S, Furutani Y, Suto Y, et al. Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract.<\/a> Microbiol Res.<\/em> Oct 17 2011.<\/li>\n
      17. Takimoto H, Wakita D, Kawaguchi K, et al. Potentiation of cytotoxic activity in naive and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies.<\/a> Biol Pharm Bull.<\/em> Mar 2004;27(3):404-406.<\/li>\n
      18. Yuminamochi E, Koike T, Takeda K, et al. Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill.<\/a> Immunology.<\/em> Jun 2007;121(2):197-206.<\/li>\n
      19. Gao L, Sun Y, Chen C, et al. Primary mechanism of apoptosis induction in a leukemia cell line by fraction FA-2-b-ss prepared from the mushroom Agaricus blazei Murill.<\/a> Braz J Med Biol Res.<\/em> Nov 2007;40(11):1545-1555.<\/li>\n
      20. Jin CY, Moon DO, Choi YH, et al. Bcl-2 and caspase-3 are major regulators in Agaricus blazei-induced human leukemic U937 cell apoptosis through dephoshorylation of Akt.<\/a> Biol Pharm Bull.<\/em> Aug 2007;30(8):1432-1437.<\/li>\n
      21. Su ZY, Tung YC, Hwang LS, et al. Blazeispirol A from Agaricus blazei fermentation product induces cell death in human hepatoma Hep 3B cells through caspase-dependent and caspase-independent pathways.<\/a> J Agric Food Chem.<\/em> May 11 2011;59(9):5109-5116.<\/li>\n
      22. Akiyama H, Endo M, Matsui T, et al. Agaritine from Agaricus blazei Murrill induces apoptosis in the leukemic cell line U937.<\/a> Biochim Biophysica Acta.<\/em> May 2011;1810(5):519-525.<\/li>\n
      23. Engdal S, Nilsen OG. In vitro inhibition of CYP3A4 by herbal remedies frequently used by cancer patients. <\/a>Phytother Res.<\/em> 2009 Jul;23(7):906-12.<\/li>\n
      24. Lee JS, Hong EK. Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NF\u03baB-mediated increase of intracellular doxorubicin accumulation.<\/a> Int J Oncol.<\/em> 2011 Feb;38(2):401-8.<\/li>\n
      25. Lima CU, Souza VC, Morita MC, Chiarello MD, Karnikowski MG. Agaricus blazei Murrill and inflammatory mediators in elderly women: a randomized clinical trial. <\/a>Scand J Immunol.<\/em> 2012 Mar;75(3):336-41.<\/li>\n<\/ol>\n

        Inonotus Obliquus \/Chaga\/<\/strong><\/h3>\n
          \n
        1. ^<\/a><\/b><\/span> „Inonotus obliquus<\/i> (Ach. ex Pers.) Pil\u00e1t 1942″<\/a>. MycoBank<\/a>. International Mycological Association. Retrieved 2011-10-11<\/span>.<\/span><\/span><\/li>\n
        2. ^<\/a><\/b><\/span> Needham, Arthur (2005-12-16). „Clinker Polypore, Chaga“<\/a>. Retrieved 10 October 2011<\/span>.<\/span><\/span><\/li>\n
        3. ^<\/a><\/b><\/span> Muma, Walter. „True Tinder Fungus“<\/a>. Retrieved 5 December 2012<\/span>.<\/span><\/span><\/li>\n
        4. ^<\/a><\/b><\/span> Youn, Myung-Ja; Kim, JK; Park, SY; Kim, Y; Kim, SJ; Lee, JS; Chai, KY; Kim, HJ; Cui, MX; So, HS; Kim, KY; Park, R (2008). „Chaga mushroom (Inonotus obliquus ) induces G0\/G1 arrest and apoptosis in human hepatoma HepG2 cells“. World Journal of Gastroenterology<\/i> 14<\/b> (4): 511\u20137. doi<\/a>:10.3748\/wjg.14.511<\/a>. PMC<\/a>\u00a02681140<\/a>. PMID<\/a>\u00a018203281<\/a>.<\/span><\/span><\/li>\n
        5. ^<\/a><\/b><\/span> „Chaga Mushroom“<\/a>. Memorial Sloan\u2013Kettering Cancer Center<\/a>. 18 July 2011. Retrieved August 2013<\/span>.<\/span><\/span><\/li>\n
        6. ^<\/a><\/b><\/span>\n