{"id":1206,"date":"2018-06-30T12:35:21","date_gmt":"2018-06-30T10:35:21","guid":{"rendered":"https:\/\/my-immunity.com\/staging\/?page_id=1206"},"modified":"2019-08-29T00:25:12","modified_gmt":"2019-08-28T22:25:12","slug":"clinical-research","status":"publish","type":"page","link":"https:\/\/my-immunity.com\/staging\/clinical-research.html","title":{"rendered":"CLINICAL RESEARCH"},"content":{"rendered":"
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Leading Universities around the world are leading the transformation of healthcare by creating\u00a0 and contributing rigorous scientific studies on the integration of complementary therapies with conventional medicine, with a focus on educational research, corporate health improvement research, and methods to study clinical outcomes in integrative medicine.<\/strong><\/p>\n

Purpose of this published studies is scientific information and education, it should not be used for diagnosing or treating a health problem or disease. This website is designed for general education and information purposes only and does not substitute for professional medical advice, examination, diagnosis or treatment.<\/u><\/strong><\/span><\/p>\n

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In the world’s largest electronic medical database maintained by the U.S. government, „MEDLINE“ <\/a><\/strong><\/span>in 2013 there<\/span> were 115 scientific articles on topic\u00a0„<\/strong>Medicinal <\/strong>Mushrooms<\/strong>and Cancer<\/strong>„<\/strong><\/a><\/strong>,<\/strong> 489 articles\u00a0 on \u00a0topic\u00a0 „Medicinal mushrooms“<\/strong><\/a>. <\/strong>Number of\u00a0 scientific articles published on most popular medicinal mushrooms:\u00a0 <\/strong>Ganoderma Lucidum\u00a0 <\/strong><\/a>(Reishi) 921, Coriolus Versicolor<\/strong><\/a> 302, Cordyceps Sinensis <\/strong><\/a>807,\u00a0 Agaricus Blazei<\/strong><\/a> 211,\u00a0 Lentinula Edodes<\/strong><\/a> (Shiitake) 502, Grifola Frondosa<\/strong><\/a> (Maitake) 244<\/strong><\/p>\n

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Clinical Trials:<\/b><\/h3>\n

Reducing the side effects: Using\u00a0Immune Assist (K9 Immunity)<\/i>\u00a0<\/b>in Cancer treatment to reduce side effects:\u00a0Cancer Clinical Trial<\/a>\u00a0\u00a0<\/b>(web page)<\/p>\n

Immune Assist<\/i><\/b>\u00a0is the human grade, the same product in veterinary packaging is named\u00a0K9 Immunity<\/i><\/b><\/p>\n

[PDF] Hybridization of Cordyceps sinensis and Quality Analysis – An article on Aloha Medicinals Cordyceps from the „International Journal of Medicinal Mushrooms<\/em>„<\/a><\/p>\n

[PDF] On The Trail of the Yak – Most complhttps:\/\/www.moj-imunitet.com\/wp-content\/uploads\/2019\/08\/Hybridization-of-Cordyceps-sinensis.pdfete article yet on Cordyceps<\/a><\/p>\n

[PDF] Immuno-modulating and Anti-tumor compounds from Medicinal Mushrooms by Dr. Solomon Wasser – Great Article!<\/a><\/p>\n

[PDF] Medicinal Properties of Substances Occuring in Higher Basidiomycetes Mushrooms: Current Perspective (Review) by Dr. Solomon Wasser – Another Great Article!<\/a><\/p>\n

Medicinal Mushrooms<\/a><\/p>\n

Official Government Publication: <\/b><\/span><\/span><\/p>\n

Cancer Research UK<\/a>: Medicinal Mushrooms: Their therapeutic properties and current medical usage with special emphasis on cancer treatments:<\/a><\/strong><\/h3>\n

by Richard Sullivan MD PhD\u00a0\u00a0 <\/em><\/span><\/a>Dr.<\/em>Richard Sullivan<\/em> is Professor<\/em> of Cancer Policy & Global Health at Kings College<\/em> London and Director of the new Kings Institute of Cancer Policy.<\/span><\/span><\/strong><\/p>\n

Table of Contents<\/a>\u00a0(PDF 8.87 kb)<\/p>\n

Preamble<\/a>\u00a0(PDF 15.5 kb)<\/p>\n

Chapter 1<\/a>\u00a0– Introduction (PDF 36.3 kb)<\/p>\n

Chapter 2<\/a>\u00a0– The Nature of Fungi with Special Emphasis on Mushrooms\u00a0 (PDF 1.41 Mb)<\/p>\n

Chapter 3a<\/a>\u00a0– Medicinally Important Mushrooms Part 1 (PDF 8.12 Mb)<\/p>\n

Chapter 3b<\/a>\u00a0– Medicinally Important Mushrooms Part 2 (PDF 8.75 Mb)<\/p>\n

Chapter 3c<\/a>\u00a0– Medicinally Important Mushrooms Part 3 (PDF 8.33 Mb)<\/p>\n

Chapter 4<\/a>\u00a0– Technology of Mushroom Cultivation (PDF 338 kb)<\/p>\n

Chapter 5<\/a>\u00a0– Extraction, Development and Chemistry of Anti-Cancer Compounds from Medicinal Mushrooms (PDF 399 kb)<\/p>\n

Chapter 6<\/a>\u00a0– Immunomodulatory Activities of Mushroom GlucansPolysaccharide-Protein Complexes in Animals and Humans (PDF 216 kb)<\/p>\n

Chapter 7<\/a>\u00a0– The Role of Polysaccharides Derived from Medicinal Mushrooms in Cancer (PDF 133 kb)<\/p>\n

Chapter 8\u00a0<\/a>– Additional Medicinal Properties (PDF 84.2 kb)<\/p>\n

Chapter 9<\/a>\u00a0– Regulatory and Safety Criteria (PDF 67.8 kb)<\/p>\n

Chapter 10<\/a>\u00a0– Conclusions(PDF 49.5 kb)<\/p>\n

Appendix 1<\/a>\u00a0– Overview of Human Immune System (PDF 603 kb)<\/p>\n

Appendix 2<\/a>\u00a0– Standard Antitumor Activity Test (PDF 12.7 kb)<\/p>\n

Appendix 3<\/a>\u00a0– Medicinal Mushrooms and Cancer Prevention (PDF 17.0 kb)<\/p>\n

Author Biographies<\/a>\u00a0(PDF 21.6 kb)<\/p>\n

Executive Summary<\/a>\u00a0(PDF 32.7 kb)<\/p>\n

Acknowledgment<\/a>\u00a0(PDF 6.89 kb)<\/p>\n

Front Cover<\/a>\u00a0(JPG 69 kb)<\/p>\n

Back Cover<\/a>\u00a0(JPG 26.29 kb)<\/p>\n

Purpose of this published study is scientific information and education, it should not be used for diagnosing or treating a health problem or disease. This website is designed for general education and information purposes only and does not substitute for professional medical advice, examination, diagnosis or treatment.<\/u><\/strong><\/span><\/p>\n


\nMemorial Sloan<\/em>\u2013Kettering Cancer Center (MSKCC)- Founded in 1884 as the New York Cancer Hospital, Memorial Sloan<\/em>–Kettering Cancer Center<\/em> (MSKCC<\/em>) is one of the oldest cancer centers in the country.<\/span><\/span><\/strong><\/a><\/p>\n

References:<\/strong><\/span><\/h3>\n
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Cordyceps Sinensis:<\/strong><\/span><\/h3>\n
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    \n
  1. Huang KC. The Pharmacology of Chinese Herbs, 2nd<\/sup>\u00a0ed. Boca Raton: CRC Press; 1999.<\/li>\n
  2. Zhu JS, Halpern GM, Jones K.\u00a0The scientific rediscovery of a precious ancient Chinese herbal regime: Cordyceps sinensis, Part I<\/a>.\u00a0J Altern Complement Med<\/em>\u00a01998;4:289-303.<\/li>\n
  3. Zhu JS, Halpern GM, Jones K.\u00a0The scientific rediscovery of a precious ancient Chinese herbal regime: Cordyceps sinensis, Part II<\/a>.\u00a0J Altern Complement Med<\/em>\u00a01998;4:429-57.<\/li>\n
  4. Xu F, et al.\u00a0Amelioration of cyclosporin nephrotoxicity by Cordyceps sinensis in kidney-transplant recipients<\/a>.\u00a0Nephrol Dial Transplant<\/em>\u00a01995;10:142-3.<\/li>\n
  5. Huang B, et al.\u00a0Cordyceps sinensis and its fractions stimulate MA-10 mouse Leydig tumor cell steroidogenesis<\/a>.\u00a0J Androl<\/em>\u00a02001;22:831-7.<\/li>\n
  6. Nakamura K, et al.\u00a0Inhibitory effect of Cordyceps sinensis on spontaneous liver metastasis of Lewis lung carcinoma and B16 melanoma cells in syngeneic mice<\/a>.\u00a0Jpn J Pharmacol<\/em>\u00a01999;79:335-41.<\/li>\n
  7. Chiu JH, et al.\u00a0Cordyceps sinensis increases the expression of major histocompatibility complex class II antigens in human hepatoma cell line HA22T\/VGH cells<\/a>.\u00a0Am J Chin Med<\/em>\u00a01998;26:59-70.<\/li>\n
  8. Li, Y. et. al.\u00a0Effect of Cordyceps sinensis on erythropoiesis in mouse bone marrow<\/a>.\u00a0Chin Med J (Engl)<\/em>. 1993 Apr;106(4):313-6.<\/li>\n
  9. Huang YL, Leu SF, Liu BC, et al.\u00a0In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse.<\/a>\u00a0Life Sci<\/em>\u00a02004 Jul 16;75(9):1051-62.<\/li>\n
  10. Wu WC, Hsiao JR, Lian YY, et al.\u00a0The apoptotic effect of cordycepin on human OEC-M1 oral cancer cell line.<\/a>Cancer Chemother Pharmacol.<\/em>\u00a02007 Jun;60(1):103-11.<\/li>\n
  11. Oh JY, Baek YM, Kim SW, et al.\u00a0Apoptosis of human hepatocarcinoma (HepG2) and neuroblastoma (SKN-SH) cells induced by polysaccharides-peptide complexes produced by submerged mycelial culture of an entomopathogenic fungus Cordyceps sphecocephala.<\/a>\u00a0J Microbiol Biotechnol.<\/em>\u00a02008 Mar;18(3):512-9.<\/li>\n
  12. Liu WC, Wang SC, Tsai ML, et al.\u00a0Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis, a Chinese herbal medicine.<\/a>\u00a0Radiat Res.<\/em>\u00a02006 Dec;166(6):900-7.<\/li>\n
  13. Liu WC, Chuang WL, Tsai ML, et al.\u00a0Cordyceps sinensis health supplement enhances recovery from taxol-induced leukopenia.<\/a>\u00a0Exp Biol Med (Maywood).<\/em>\u00a02008 Apr;233(4):447-55.<\/li>\n
  14. Kubo E, Yoshikawa N, Kunitomo M, et al.\u00a0Inhibitory effect of Cordyceps sinensis on experimental hepatic metastasis of melanoma by suppressing tumor cell invasion.<\/a>\u00a0Anticancer Res.<\/em>\u00a02010 Sep;30(9):3429-33.<\/li>\n
  15. Lo HC, Hsu TH, Tu ST, Lin KC.\u00a0Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin.<\/a>\u00a0Am J Chin Med.<\/em>\u00a02006;34(5):819-32.<\/li>\n
  16. Shi B, Wang Z, Jin H, et al.\u00a0Immunoregulatory Cordyceps sinensis increases regulatory T cells to Th17 cell ratio and delays diabetes in NOD mice.<\/a>\u00a0Int Immunopharmacol.<\/em>\u00a02009 May;9(5):582-6.<\/li>\n
  17. Ji NF, Yao LS, Li Y, et al.\u00a0Polysaccharide of Cordyceps sinensis Enhances Cisplatin Cytotoxicity in Non-Small Cell Lung Cancer H157 Cell Line.<\/a>\u00a0Integr Cancer Ther.<\/em>\u00a02011;10(4):359-67.<\/li>\n
  18. Zhang Z, Wang X, Zhang Y, Ye G.\u00a0Effect of Cordyceps sinensis on Renal Function of Patients with Chronic Allograft Nephropathy.<\/a>\u00a0Urol Int.<\/em>\u00a02011;86(3):298-301.<\/li>\n<\/ol>\n

    Coriolus Versicolor<\/strong><\/h3>\n
      \n
    1. Nakazato H, et al.\u00a0Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study Group of Immunochemotherapy with PSK for Gastric Cancer.<\/a>\u00a0Lancet<\/em>\u00a01994; 343(8906): 1122-6.<\/li>\n
    2. Niimoto M, et al.\u00a0Postoperative adjuvant immunochemotherapy with mitomycin C, futraful and PSK for gastric cancer. An analysis of data on 579 patients followed for five years.<\/a>\u00a0Jpn J Surg<\/em>\u00a01988; 18(6): 681-6.<\/li>\n
    3. Ohwada S, et al.\u00a0Adjuvant immunochemotherapy with oral Tegafur\/Uracil plus PSK in patients with stage II or III colorectal cancer: a randomised controlled study.<\/a>\u00a0Br J Cancer<\/em>\u00a02004; 90(5): 1003-10.<\/li>\n
    4. Mitomi T, et al.\u00a0Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanagawa).<\/a>\u00a0Dis Colon Rectum<\/em>\u00a01992; 35(2): 123-30.<\/li>\n
    5. Torisu M, et al.\u00a0Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer.<\/a>\u00a0Cancer Immunol Immunother<\/em>\u00a01990; 31(5): 261-8.<\/li>\n
    6. Tsang KW, et al.\u00a0Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer.<\/a>\u00a0Respir Med<\/em>\u00a02003; 97(6): 618-24.<\/li>\n
    7. Wong CK, et al.\u00a0Immunomodulatory effects of yun zhi and danshen capsules in health subjects\u2014a randomized, double-blind, placebo-controlled, crossover study.<\/a>\u00a0Int Immunopharmacol<\/em>\u00a02004; 4(2): 201-11.<\/li>\n
    8. Wong CK, et al.\u00a0Immunomodulatory activities of Yunzhi and Danshen in post-treatment breast cancer patients.<\/a>\u00a0Am J Chin Med<\/em>\u00a02005; 33(3): 381-95.<\/li>\n
    9. Iino Y, et al.\u00a0Immunochemotherapies versus chemotherapy as adjuvant treatment after curative resection of operable breast cancer.<\/a>\u00a0Anticancer Res<\/em>\u00a01995; 15(6B): 2907-11.<\/li>\n
    10. Suto T, et al.\u00a0Clinical study of biological response modifiers as maintenance therapy for hepatocellular carcinoma.\u00a0<\/a>Cancer Chemother Pharmacol<\/em>\u00a01994; 33: S145-8.<\/li>\n
    11. Ohno R, et al.\u00a0A randomized trial of chemoimmunotherapy of acute nonlymphocytic leukemia in adults using a protein-bound polysaccharide preparation.<\/a>\u00a0Cancer Immunol Immunother<\/em>\u00a01984; 18(3): 149-54.<\/li>\n
    12. Toth B, Coles M, Lynch J.\u00a0Effects of VPS extract of Coriolus versicolor on cancer of the large interstine using a serial sacrifice technique.<\/a>\u00a0In Vivo<\/em>\u00a02006;20(3):341-6.<\/li>\n
    13. Yang X, et al.\u00a0The cell death process of the anticancer agent polysaccharide-peptide (PSP) in human promyelocytic leukemic HL-60 cells.<\/a>\u00a0Oncol Rep<\/em>\u00a02005; 13(6): 1201-10.<\/li>\n
    14. Wan JMF, Sit WH, Yang X, Jiang P, Wong LY.\u00a0Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT) on human leukemia HL-60 cells.<\/a>\u00a0Chinese Medicine.<\/em>2010;5:16.<\/li>\n
    15. Jiang J, Sliva D.\u00a0Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells.<\/a>\u00a0Int J Oncol.<\/em>\u00a02010 Dec;37(6):1529-36.<\/li>\n
    16. Collins RA, Ng TB.\u00a0Polysaccharopeptide from Coriolus versicolor has Potential for Use Against Human Immunodeficiency Virus type I Infection.<\/a>\u00a0Pharmcology Letters<\/em>\u00a01997; 60(25): 387-387.<\/li>\n
    17. Tsukagoshi S, et al.\u00a0Krestin (PSK).<\/a>\u00a0Cancer Treat Rev<\/em>\u00a01984; 11(2): 131-55.<\/li>\n
    18. Liu WK, et al.\u00a0Activation of peritoneal macrophages by polysaccharopeptide from the mushroom, Coriolus versicolor.<\/a>\u00a0Immunopharmacology<\/em>\u00a01993; 26(2): 139-46.<\/li>\n
    19. Ng TB, Chan WY.\u00a0Polysaccharopeptide from the mushroom Coriolus versicolor possesses analgesic activity but does not produce adverse effects on female reproductive or embryonic development in mice.<\/a>\u00a0Gen Pharmacol<\/em>1997; 29(2): 269-73.<\/li>\n
    20. Kato M, et al.\u00a0Induction of gene expression for immunomodulating cytokines in peripheral blood mononuclear cells in response to orally administered PSK, an immunomodulating protein-bound polysaccharide.<\/a>\u00a0Cancer Immunol Immunother<\/em>\u00a01995; 40(3): 152-6.<\/li>\n
    21. Shiu WCT, et al. A Clinical Study of PSP on Peripheral Blood Counts during Chemotherapy.\u00a0Phytotherapy Research<\/em>\u00a01992; (6): 217-218.<\/li>\n
    22. Kidd, PM.\u00a0The use of mushroom glucans and proteoglycans in cancer treatment.<\/a>\u00a0Altern Med Rev<\/em>\u00a02000 5(1): 4-27.<\/li>\n
    23. Lau CB, et al.\u00a0Cytotoxic activities of Coriolus versicolor (Yunzhi) extract on human leukemia and lymphoma cells by induction of apoptosis.<\/a>\u00a0Life Sci<\/em>\u00a02004; 75(7): 797-808.<\/li>\n
    24. Hirahara N, Edamatsu T, Fujieda A,\u00a0et al.\u00a0Protein-bound polysaccharide-K (PSK) induces apoptosis via p38 mitogen-activated protein kinase pathway in promyelomonocytic leukemia HL-60 cells.<\/a>\u00a0Anticancer Res.\u00a0<\/em>2012 Jul;32(7):2631-7.<\/li>\n<\/ol>\n

      Agaricus Blazei<\/strong><\/h3>\n
        \n
      1. Fujimiya Y, Suzuki Y, Oshiman K, et al.\u00a0Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis.<\/a>\u00a0Cancer Immunol Immunother.<\/em>\u00a0May 1998;46(3):147-159.<\/li>\n
      2. Itoh H, Ito H, Amano H, et al.\u00a0Inhibitory action of a (1\u2014>6)-beta-D-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murill (\u201chimematsutake\u201d) on Meth A fibrosarcoma-bearing mice and its antitumor mechanism.<\/a>\u00a0Jpn J Pharmacol.<\/em>\u00a0Oct 1994;66(2):265-271.<\/li>\n
      3. Kimura Y, Kido T, Takaku T, et al.\u00a0Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions.<\/a>\u00a0Cancer Sci.<\/em>\u00a0Sep 2004;95(9):758-764.<\/li>\n
      4. Lee YL, Kim HJ, Lee MS, et al.\u00a0Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model.<\/a>\u00a0Exp Anim.<\/em>\u00a0Oct 2003;52(5):371-375.<\/li>\n
      5. Mizuno M, Morimoto M, Minato K, et al.\u00a0Polysaccharides from Agaricus blazei stimulate lymphocyte T-cell subsets in mice.<\/a>\u00a0Biosci Biotechnol Biochem.<\/em>\u00a0Mar 1998;62(3):434-437.<\/li>\n
      6. Takaku T, Kimura Y, Okuda H.\u00a0Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action.<\/a>\u00a0J Nutr.<\/em>\u00a0May 2001;131(5):1409-1413.<\/li>\n
      7. Ahn WS, Kim DJ, Chae GT, et al.\u00a0Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy.<\/a>\u00a0Int J Gynecol Cancer.<\/em>\u00a0Jul-Aug 2004;14(4):589-594.<\/li>\n
      8. Gray AM, Flatt PR.\u00a0Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom).<\/a>\u00a0J Endocrinol.<\/em>May 1998;157(2):259-266.<\/li>\n
      9. Swanston-Flatt SK, Day C, Flatt PR, et al.\u00a0Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice.<\/a>\u00a0Diabetes Res.<\/em>\u00a0Feb 1989;10(2):69-73.<\/li>\n
      10. Kim YW, Kim KH, Choi HJ, et al.\u00a0Anti-diabetic activity of beta-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei.<\/a>\u00a0Biotechnol Lett.<\/em>\u00a0Apr 2005;27(7):483-487.<\/li>\n
      11. Hsu CH, Liao YL, Lin SC, et al.\u00a0The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial.<\/a>J Altern Complement Med.<\/em>\u00a0Jan-Feb 2007;13(1):97-102.<\/li>\n
      12. Liu Y, Fukuwatari Y, Okumura K, et al.\u00a0Immunomodulating Activity of Agaricus brasiliensis KA21 in Mice and in Human Volunteers.<\/a>\u00a0Evid Based Complement Alternat Med.<\/em>\u00a0Jun 2008;5(2):205-219.<\/li>\n
      13. Hsu CH, Hwang KC, Chiang YH, et al.\u00a0The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B.<\/a>\u00a0J Altern Complement Med.<\/em>\u00a0Apr 2008;14(3):299-301.<\/li>\n
      14. Mukai H, Watanabe T, Ando M, et al.\u00a0An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients.<\/a>\u00a0Jpn J Clin Oncol.<\/em>\u00a0Dec 2006;36(12):808-810.<\/li>\n
      15. Suehiro M, Katoh N, Kishimoto S.\u00a0Cheilitis due to Agaricus blazei Murill mushroom extract.<\/a>\u00a0Contact Dermatitis.<\/em>May 2007;56(5):293-294.<\/li>\n
      16. Dong S, Furutani Y, Suto Y, et al.\u00a0Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract.<\/a>\u00a0Microbiol Res.<\/em>\u00a0Oct 17 2011.<\/li>\n
      17. Takimoto H, Wakita D, Kawaguchi K, et al.\u00a0Potentiation of cytotoxic activity in naive and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies.<\/a>\u00a0Biol Pharm Bull.<\/em>\u00a0Mar 2004;27(3):404-406.<\/li>\n
      18. Yuminamochi E, Koike T, Takeda K, et al.\u00a0Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill.<\/a>\u00a0Immunology.<\/em>\u00a0Jun 2007;121(2):197-206.<\/li>\n
      19. Gao L, Sun Y, Chen C, et al.\u00a0Primary mechanism of apoptosis induction in a leukemia cell line by fraction FA-2-b-ss prepared from the mushroom Agaricus blazei Murill.<\/a>\u00a0Braz J Med Biol Res.<\/em>\u00a0Nov 2007;40(11):1545-1555.<\/li>\n
      20. Jin CY, Moon DO, Choi YH, et al.\u00a0Bcl-2 and caspase-3 are major regulators in Agaricus blazei-induced human leukemic U937 cell apoptosis through dephoshorylation of Akt.<\/a>\u00a0Biol Pharm Bull.<\/em>\u00a0Aug 2007;30(8):1432-1437.<\/li>\n
      21. Su ZY, Tung YC, Hwang LS, et al.\u00a0Blazeispirol A from Agaricus blazei fermentation product induces cell death in human hepatoma Hep 3B cells through caspase-dependent and caspase-independent pathways.<\/a>\u00a0J Agric Food Chem.<\/em>\u00a0May 11 2011;59(9):5109-5116.<\/li>\n
      22. Akiyama H, Endo M, Matsui T, et al.\u00a0Agaritine from Agaricus blazei Murrill induces apoptosis in the leukemic cell line U937.<\/a>\u00a0Biochim Biophysica Acta.<\/em>\u00a0May 2011;1810(5):519-525.<\/li>\n
      23. Engdal S, Nilsen OG.\u00a0In vitro inhibition of CYP3A4 by herbal remedies frequently used by cancer patients.\u00a0<\/a>Phytother Res.<\/em>\u00a02009 Jul;23(7):906-12.<\/li>\n
      24. Lee JS, Hong EK.\u00a0Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NF\u03baB-mediated increase of intracellular doxorubicin accumulation.<\/a>\u00a0Int J Oncol.<\/em>\u00a02011 Feb;38(2):401-8.<\/li>\n
      25. Lima CU, Souza VC, Morita MC, Chiarello MD, Karnikowski MG.\u00a0Agaricus blazei Murrill and inflammatory mediators in elderly women: a randomized clinical trial.\u00a0<\/a>Scand J Immunol.<\/em>\u00a02012 Mar;75(3):336-41.<\/li>\n<\/ol>\n

        Inonotus Obliquus \/Chaga\/<\/strong><\/h3>\n
          \n
        1. ^<\/a><\/b><\/span>\u00a0„Inonotus obliquus<\/i>\u00a0(Ach. ex Pers.) Pil\u00e1t 1942″<\/a>.\u00a0MycoBank<\/a>. International Mycological Association. Retrieved 2011-10-11<\/span>.<\/span><\/span><\/li>\n
        2. ^<\/a><\/b><\/span>\u00a0Needham, Arthur (2005-12-16).\u00a0„Clinker Polypore, Chaga“<\/a>. Retrieved 10 October 2011<\/span>.<\/span><\/span><\/li>\n
        3. ^<\/a><\/b><\/span>\u00a0Muma, Walter.\u00a0„True Tinder Fungus“<\/a>. Retrieved 5 December 2012<\/span>.<\/span><\/span><\/li>\n
        4. ^<\/a><\/b><\/span>\u00a0Youn, Myung-Ja; Kim, JK; Park, SY; Kim, Y; Kim, SJ; Lee, JS; Chai, KY; Kim, HJ; Cui, MX; So, HS; Kim, KY; Park, R (2008). „Chaga mushroom (Inonotus obliquus ) induces G0\/G1 arrest and apoptosis in human hepatoma HepG2 cells“.\u00a0World Journal of Gastroenterology<\/i>\u00a014<\/b>\u00a0(4): 511\u20137.\u00a0doi<\/a>:10.3748\/wjg.14.511<\/a>.\u00a0PMC<\/a>\u00a02681140<\/a>.\u00a0PMID<\/a>\u00a018203281<\/a>.<\/span><\/span><\/li>\n
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